Dasabuvir ( ABT-333 )

产品货号. M10464 CAS No. 1132935-63-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Dasabuvir
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ABT-333 是一种 NS5B 非核苷聚合酶抑制剂。
产品描述

ABT-333 is an NS5B non-nucleoside polymerase inhibitor.(In Vitro):Dasabuvir (ABT-333) is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.Dasabuvir (ABT-333) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM.Dasabuvir (ABT-333) inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively.
体外实验

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体内实验

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同义词

ABT-333
通路

Microbiology/Virology
靶点

HCV
受体

NS5B polymerase
研究领域

Infection
适应症

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CAS Number

1132935-63-7
分子量

493.578
分子式

C26H27N3O5S
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 46 mg/mL
SMILES

CS(=O)(NC1=CC=C2C=C(C3=CC(N(C(N4)=O)C=CC4=O)=CC(C(C)(C)C)=C3OC)C=CC2=C1)=O
化学全称

N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide

1. Poordad F, et al. Exploratory study of oral combination antiviral therapy for hepatitis C. N Engl J Med. 2013 Jan 3;368(1):45-53.

计算器

产品手册

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